Nyssa intercepted Thea Queen and Roy Harper, as they were both leaving the city, and informed Thea of the threat the group posed. She sought help from Team Archer to get a mysterious box that Malcolm had left, but they needed to get it before the League of Thanatos. With the help of Oliver Queen, The Queen, Roy Harper, Felicity Smoak and John Diggle, she managed to get a map that revealed the existence of several Lazarus Wells around the world. Together with Thea and Roy, Nyssa went after these remaining Wells to destroy them so that no one can use them for evil, just as her father, Ra's al Ghul, had done.
In a possible future, Nyssa trained Mia Smoak, daughter of Oliver and Felicity. She trained her through the years, starting in her childhood until the beginning of her adult life.