House is an infectious disease and nephrologist who stands out not only for his ability to make excellent differential diagnoses, but also for his bad mood, skepticism and his distance from patients, antisocial behavior (misanthropy), as he considers it completely unnecessary to interact with they. House commonly conflicts with hospital doctors, including his own diagnostic team, because most of his diagnoses about patients' illnesses are based on controversial and unlikely hypotheses. Her disregard for standard hospital rules and procedures often creates friction with her boss, hospital administrator and dean of the medical school Dr.
Lisa Cuddy (Lisa Edelstein). House's only true friend is Dr. James Wilson (Robert Sean Leonard), head of the oncology department. During the first three seasons, House's diagnostic team consists of Dr. Robert Chase (Jesse Spencer), Dr. Alisson Cameron (Jennifer Morrison) and Dr. Eric Foreman (Omar Epps).